CD74

Across TCGA patient cohorts, CD74 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,731 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD74-associated proteins across cancer lineages are PSMB10, LAP3, and LSP1. Each is linked with CD74 in more than 9 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD74 versus PSMB10 in HNSC, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSMB10 →	+0.551	+1.182	<.001	<.001	3	10
HNSC	LAP3 →	+0.717	+1.204	<.001	<.001	3	10
GBM	LSP1 →	+0.658	+0.959	<.001	<.001	3	10
UCEC	HLA-DPA1 →	+1.045	+1.167	<.001	<.001	3	10
UCEC	HLA-DPB1 →	+0.798	+1.423	<.001	<.001	3	10
OV	HLA-DRA →	+0.989	+1.195	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,731 associations by consensus.

CD74 vs PSMB10 — HNSC

Explore this scatter interactively →