CD74

Across TCGA patient cohorts, CD74 protein abundance is significantly associated with the RNA expression of many other genes, with 17,427 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD74-associated genes across cancer lineages are CIITA, HLA-DOA, and HLA-DMA. Each is linked with CD74 in more than 9 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD74 versus CIITA in OV, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CIITA →	+1.379	+0.710	<.001	.001	3	10
HNSC	HLA-DOA →	+1.944	+0.988	<.001	<.001	3	10
HNSC	HLA-DMA →	+1.766	+1.112	<.001	<.001	3	10
HNSC	HLA-DPB1 →	+1.872	+1.080	<.001	<.001	3	10
COAD	CASP1 →	+1.126	+0.447	<.001	<.001	3	9
HNSC	HLA-DQB1 →	+2.235	+0.984	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,427 associations by consensus.

CD74 vs CIITA — OV

Explore this scatter interactively →