CD74

Across TCGA patient cohorts, CD74 mutation is significantly associated with the RNA expression of many other genes, with 1,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD74-associated genes across cancer lineages are RN7SL248P, TMEM269, and ACO1. Each is linked with CD74 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by CD74-low versus CD74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.077	+3.500	<.001	.002	3	2
UCEC	TMEM269 →	+0.220	+3.476	<.001	.003	3	2
UCEC	ACO1 →	+0.501	+3.601	.005	.001	3	2
UCEC	ARMC7 →	+0.559	+2.939	.001	<.001	3	2
SKCM	LINC01030 →	+0.187	+3.584	<.001	.006	3	2
SKCM	JPT1P1 →	+0.166	+2.885	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,393 associations by consensus.

RN7SL248P by CD74 expression — UCEC

Explore this box plot interactively →