CD70

Across TCGA patient cohorts, CD70 protein abundance is significantly associated with the RNA expression of many other genes, with 1,466 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CD70-associated genes across cancer lineages are SEMA6D, NBL1, and ACTBL2. Each is linked with CD70 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD70-to-partner and partner-to-CD70 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD70 versus SEMA6D in LSCC, with a Pearson correlation of -0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD70→partner) and Y-score (partner→CD70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEMA6D →	-3.256	-1.166	.001	.004	3	2
CCRCC	NBL1 →	+0.990	+1.010	<.001	<.001	3	2
CCRCC	ACTBL2 →	+0.323	+0.884	.001	<.001	3	2
HNSC	LINP1 →	+1.617	+1.372	.006	.004	3	2
GBM	RPL12P35 →	+0.616	+0.843	<.001	.001	3	2
CCRCC	APOL1 →	+1.039	+0.600	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,466 associations by consensus.

CD70 vs SEMA6D — LSCC

Explore this scatter interactively →