CD70

Across TCGA pan-cancer cohorts, CD70 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CD70’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CD70 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD70 is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where CD70 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD70 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+5.839	<.001	12	view →
HNSC	Female	All	+1.780	<.001	12	view →
KIRP	All	III,IV	+3.897	<.001	11	view →
THCA	Male	All	+1.425	<.001	9	view →
STAD	All	All	+1.026	.003	7	view →
COAD	All	All	+0.848	<.001	7	view →
LUAD	All	All	+0.725	<.001	7	view →
LUSC	All	All	+0.865	.001	3	view →
LIHC	All	All	+0.281	.015	2	view →
CHOL	Female	All	+1.020	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CD70–KIRC

Open the KIRC breakdown →