CD70

Across TCGA patient cohorts, CD70 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD70-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Mre11. Each is linked with CD70 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD70-to-partner and partner-to-CD70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CD70-low versus CD70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD70→partner) and Y-score (partner→CD70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.324	-3.321	.013	.010	3	1
UCEC	MEK1 →	+0.476	+3.321	.013	.010	3	1
UCEC	Mre11 →	-0.090	-3.321	.046	.010	3	1
UCEC	P-Cadherin →	-0.203	-2.999	.007	.035	3	1
UCEC	Rb →	+0.184	+3.335	.049	.005	3	1
UCEC	TIGAR →	+0.243	+3.348	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by CD70 expression — UCEC

Explore this box plot interactively →