CD58

Across TCGA patient cohorts, CD58 protein abundance is significantly associated with the RNA expression of many other genes, with 8,447 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CD58-associated genes across cancer lineages are ITGB4, NAP1L4P1, and GJB3. Each is linked with CD58 in more than 4 cancer types. Because this analysis shows association rather than direction, both CD58-to-partner and partner-to-CD58 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD58 versus ITGB4 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD58→partner) and Y-score (partner→CD58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGB4 →	+1.212	+0.355	<.001	<.001	3	5
LSCC	NAP1L4P1 →	+0.658	+0.434	<.001	<.001	3	5
BRCA	GJB3 →	+1.814	+0.414	<.001	<.001	3	5
HNSC	IL1A →	+1.906	+0.441	<.001	<.001	3	4
GBM	SQOR →	+0.743	+0.285	<.001	.002	3	4
BRCA	LNCAROD →	+0.933	+0.366	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,447 associations by consensus.

CD58 vs ITGB4 — BRCA

Explore this scatter interactively →