CD58

Across TCGA pan-cancer cohorts, CD58 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CD58’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CD58 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD58 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where CD58 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD58 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.915	<.001	12	view →
KIRC	Female	All	+0.734	<.001	12	view →
KICH	Female	II,III,IV	−2.490	<.001	11	view →
THCA	Male	III,IV	+1.095	<.001	10	view →
LIHC	Male	III,IV	+1.526	<.001	9	view →
LUAD	All	III,IV	−0.751	<.001	8	view →
KIRP	All	All	+0.367	.019	5	view →
CHOL	All	All	+3.002	<.001	3	view →
LUSC	All	All	−0.364	.004	3	view →
ESCA	All	All	+1.109	.008	2	view →
STAD	All	II,III,IV	+0.449	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CD58–HNSC

Open the HNSC breakdown →