CD58

Across TCGA patient cohorts, CD58 mutation is significantly associated with the RNA expression of many other genes, with 2,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD58-associated genes across cancer lineages are DAZ1, C4B-AS1, and RPL23AP94. Each is linked with CD58 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD58-to-partner and partner-to-CD58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ1 grouped by CD58-low versus CD58-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD58→partner) and Y-score (partner→CD58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DAZ1 →	+0.003	+7.471	<.001	.008	3	2
BRCA	C4B-AS1 →	+0.018	+5.683	.002	.004	3	2
UCEC	RPL23AP94 →	+0.146	+1.881	.004	.003	3	2
UCEC	TEMN3-AS1 →	+0.168	+2.464	<.001	.007	3	2
UCEC	SCARNA21B →	+0.228	+2.239	.001	.003	3	2
UCEC	RNA5SP164 →	+0.086	+3.812	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

DAZ1 by CD58 expression — BRCA

Explore this box plot interactively →