CD58

Across TCGA patient cohorts, CD58 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD58-associated genes across cancer lineages are FASN, STAT3_pY705, and TFRC. Each is linked with CD58 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD58-to-partner and partner-to-CD58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CD58-low versus CD58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD58→partner) and Y-score (partner→CD58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.327	+3.459	.044	.005	3	2
UCEC	STAT3_pY705 →	-0.339	-1.807	.001	.027	3	2
UCEC	TFRC →	+0.731	+3.169	<.001	.018	3	2
UCEC	ASNS →	+0.396	+2.584	.007	.010	3	2
UCEC	C-Raf →	+0.227	+3.584	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.104	-1.794	.011	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

FASN by CD58 expression — UCEC

Explore this box plot interactively →