CD58

Across TCGA cell cohorts, CD58 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CD58-associated genes across cancer lineages are KIR3DL2, WSCD2, and ASB11. Each is linked with CD58 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD58-to-partner and partner-to-CD58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL2 grouped by CD58-low versus CD58-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD58→partner) and Y-score (partner→CD58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIR3DL2 →	+0.050	+2.878	<.001	.009	3	1
LARGE_INTESTINE	WSCD2 →	+0.123	+3.660	<.001	.005	3	1
BLOOD_Lymphoma	ASB11 →	+0.032	+3.765	<.001	.001	3	1
BLOOD_Lymphoma	OR51Q1 →	+0.080	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	GKN1 →	+0.506	+3.765	<.001	.001	3	1
BLOOD_Lymphoma	OR5P2 →	+0.020	+3.867	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KIR3DL2 by CD58 expression — LARGE_INTESTINE

Explore this box plot interactively →