CD53

Across TCGA cell cohorts, CD53 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CD53-associated genes across cancer lineages are TEX47, MAGEB18, and OR5T2. Each is linked with CD53 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD53-to-partner and partner-to-CD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX47 grouped by CD53-low versus CD53-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD53→partner) and Y-score (partner→CD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX47 →	+0.166	+4.044	.001	.009	3	1
LUNG_SCLC	MAGEB18 →	+0.012	+4.269	.009	.005	3	1
LUNG_SCLC	OR5T2 →	+0.015	+4.643	<.001	.004	3	1
LUNG_SCLC	CASP12 →	+0.087	+4.269	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TEX47 by CD53 expression — LUNG_SCLC

Explore this box plot interactively →