CD48

Across TCGA patient cohorts, CD48 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD48-associated genes across cancer lineages are FoxM1, Caveolin-1, and p38-MAPK. Each is linked with CD48 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD48-to-partner and partner-to-CD48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CD48-low versus CD48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD48→partner) and Y-score (partner→CD48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.263	+2.584	.029	.011	3	2
UCEC	Caveolin-1 →	-0.709	-2.999	.036	.035	3	2
SKCM	p38-MAPK →	+0.238	+3.459	.005	.005	3	1
SKCM	YB-1 →	-0.217	-3.157	.034	.018	3	1
UCEC	FASN →	+0.438	+3.321	.017	.010	2	2
UCEC	FOXO3a_pS318_S321 →	-0.144	-3.312	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by CD48 expression — UCEC

Explore this box plot interactively →