CD48

Across TCGA pan-cancer cohorts, CD48 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CD48’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CD48 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD48 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where CD48 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD48 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.348	<.001	12	view →
COAD	All	III,IV	−1.543	<.001	11	view →
LUSC	Male	III,IV	−2.637	<.001	8	view →
BLCA	All	All	−1.167	.005	6	view →
LUAD	All	II,III,IV	−0.614	.010	5	view →
BRCA	All	All	+0.386	.005	4	view →
KICH	All	II,III,IV	−0.985	.004	3	view →
KIRP	All	All	+0.913	.002	3	view →
READ	All	All	−1.339	.031	2	view →
UCEC	All	All	−0.895	<.001	2	view →
THCA	All	All	−0.622	.031	2	view →
THCA	Male	IV	+1.189	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CD48–KIRC

Open the KIRC breakdown →