CD44

Across TCGA patient cohorts, CD44 mutation is significantly associated with the RNA expression of many other genes, with 2,623 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD44-associated genes across cancer lineages are RNA5SP412, LINC02025, and CT55. Each is linked with CD44 in more than 3 cancer types. Because this analysis shows association rather than direction, both CD44-to-partner and partner-to-CD44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by CD44-low versus CD44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD44→partner) and Y-score (partner→CD44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.785	+2.329	<.001	<.001	3	4
LUAD	LINC02025 →	+0.089	+4.792	<.001	.002	3	3
LIHC	CT55 →	+0.841	+3.917	<.001	.004	3	2
LIHC	SPANXC →	+0.233	+3.645	<.001	.006	3	2
LIHC	MIR548XHG →	+1.215	+3.675	<.001	.007	3	2
LUAD	LINC01795 →	+0.286	+3.250	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,623 associations by consensus.

RNA5SP412 by CD44 expression — UCEC

Explore this box plot interactively →