CD44

Across TCGA pan-cancer cohorts, CD44 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CD44 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CD44 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CD44 expression acts as an unfavorable survival marker, although some lineages such as LAML and THCA show a favorable association.

KIRP, MESO, and LGG are the cancer types where CD44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.127	0.774	.002	55	view →
MESO	OS	Median	All	0.271	0.488	.001	53	view →
LGG	DFS	Median	All	0.673	0.803	<.001	52	view →
KIRC	DFS	Quartile	II,III,IV	0.360	0.653	.001	48	view →
SCLC	DFS	Tertile	All	0.328	0.905	.002	37	view →
PAAD	OS	Median	All	0.506	0.753	.001	37	view →
STAD	OS	Median	All	0.505	0.650	.004	25	view →
GBM	DFS	Quartile	All	0.183	0.369	<.001	25	view →
LAML	DFS	Quartile	All	0.574	0.249	.002	22	view →
HNSC	OS	Median	IV	0.493	0.769	.004	22	view →
THCA	OS	Median	II,III,IV	0.992	0.907	.002	21	view →
CHOL	DFS	Quartile	All	0.608	0.211	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CD44–KIRP (OS)

Open the KIRP breakdown →