CD44

Across TCGA patient cohorts, CD44 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD44-associated genes across cancer lineages are mTOR_pS2448, VHL, and Caspase-7-cleavedD198. Each is linked with CD44 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD44-to-partner and partner-to-CD44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CD44-low versus CD44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD44→partner) and Y-score (partner→CD44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.128	-1.906	.032	.016	3	2
UCEC	VHL →	-1.028	-3.700	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.522	+2.189	.028	.034	3	2
UCEC	Cyclin-E1 →	+0.388	+2.321	.026	.034	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.115	.022	.017	3	1
UCEC	eIF4G →	+0.275	+2.321	.027	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by CD44 expression — UCEC

Explore this box plot interactively →