CD44

Across TCGA cell cohorts, CD44 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,063 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CD44-associated GO terms across cancer lineages are Leukocyte aggregation, Monocyte aggregation, and Regulation of monocyte aggregation. Each is linked with CD44 in more than 17 cancer types. Because this analysis shows association rather than direction, both CD44-to-partner and partner-to-CD44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leukocyte aggregation grouped by CD44-low versus CD44-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD44→partner) and Y-score (partner→CD44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Leukocyte aggregation →	+0.586	+4.481	.003	<.001	3	18
BONE	Monocyte aggregation →	+1.783	+5.955	<.001	<.001	3	18
BONE	Regulation of monocyte aggregation →	+1.928	+5.958	<.001	<.001	3	15
BONE	Positive regulation of monocyte aggregation →	+1.928	+5.958	<.001	<.001	3	15
BONE	Positive regulation of heterotypic cell-cell adhesion →	+1.567	+5.405	<.001	<.001	3	15
BONE	Negative regulation of plasminogen activation →	+1.050	+5.605	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,063 associations by consensus.

Leukocyte aggregation by CD44 expression — LIVER

Explore this box plot interactively →