CD44-AS1

Across TCGA pan-cancer cohorts, CD44-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CD44-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CD44-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CD44-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

KIRC, LGG, and KIRP are the cancer types where CD44-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.541	0.695	<.001	142	view →
LGG	DFS	Median	All	0.654	0.816	<.001	53	view →
KIRP	OS	Quartile	III,IV	0.111	0.701	.001	50	view →
STAD	DFS	Quartile	III,IV	0.477	0.750	.001	46	view →
COAD	DFS	Median	All	0.399	0.692	.005	34	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
GBM	DFS	Quartile	All	0.177	0.312	.010	15	view →
MESO	OS	Median	II,III,IV	0.296	0.750	.002	15	view →
THYM	DFS	Tertile	All	0.840	0.982	.012	15	view →
ACC	OS	Quartile	All	0.310	0.654	.025	14	view →
CHOL	DFS	Quartile	All	0.688	0.330	.019	12	view →
LAML	DFS	Tertile	All	0.701	0.432	.030	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CD44-AS1–KIRC (DFS)

Open the KIRC breakdown →