CD44-AS1

Across TCGA pan-cancer cohorts, CD44-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CD44-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CD44-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD44-AS1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, THCA, and READ are the cancer types where CD44-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD44-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.833	<.001	8	view →
THCA	All	All	+0.677	<.001	8	view →
READ	All	All	+1.357	<.001	7	view →
COAD	Male	All	+1.026	<.001	7	view →
KIRC	Male	All	+0.176	.002	4	view →
LUAD	Male	All	−0.531	.042	1	view →
LUSC	Male	All	+0.419	.032	1	view →
KICH	All	All	+0.334	.019	1	view →
KIRP	All	All	+0.308	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CD44-AS1–HNSC

Open the HNSC breakdown →