CD40

Across TCGA patient cohorts, CD40 mutation is significantly associated with the RNA expression of many other genes, with 728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD40-associated genes across cancer lineages are ANKHD1, PRELID3BP5, and OR10G3. Each is linked with CD40 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD40-to-partner and partner-to-CD40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKHD1 grouped by CD40-low versus CD40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40→partner) and Y-score (partner→CD40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANKHD1 →	+0.353	+3.721	<.001	<.001	3	2
BLCA	PRELID3BP5 →	+0.238	+3.873	<.001	.004	3	2
BLCA	OR10G3 →	+0.040	+4.788	<.001	<.001	3	2
BLCA	MIR147A →	+0.411	+4.588	<.001	<.001	3	2
HNSC	LINC00358 →	+0.025	+4.822	<.001	.006	3	2
HNSC	RNA5SP61 →	+0.316	+5.339	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 728 associations by consensus.

ANKHD1 by CD40 expression — UCEC

Explore this box plot interactively →