CD4

Across TCGA patient cohorts, CD4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD4-associated genes across cancer lineages are ASNS, TIGAR, and ACC1. Each is linked with CD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD4-to-partner and partner-to-CD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CD4-low versus CD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD4→partner) and Y-score (partner→CD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.500	+1.700	<.001	.042	3	3
SKCM	TIGAR →	+0.142	+2.820	.044	.035	2	3
UCEC	ACC1 →	+0.302	+3.013	.034	.018	3	1
UCEC	MEK1 →	+0.328	+2.000	.022	.030	3	1
UCEC	mTOR_pS2448 →	-0.136	-2.565	.020	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.176	+1.598	.029	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ASNS by CD4 expression — UCEC

Explore this box plot interactively →