CD3G

Across TCGA patient cohorts, CD3G mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD3G-associated genes across cancer lineages are Notch1, Rab25, and PDCD4. Each is linked with CD3G in more than 1 cancer types. Because this analysis shows association rather than direction, both CD3G-to-partner and partner-to-CD3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CD3G-low versus CD3G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD3G→partner) and Y-score (partner→CD3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.294	+2.820	<.001	.035	3	1
UCEC	Rab25 →	-0.510	-3.000	.007	.037	3	1
UCEC	PDCD4 →	-0.791	-2.990	.003	.036	2	1
UCEC	Ku80 →	+0.298	+3.013	.029	.019	1	1
UCEC	PR →	-0.346	-3.000	.017	.037	1	1
UCEC	Bcl-2 →	-0.542	-2.973	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by CD3G expression — UCEC

Explore this box plot interactively →