CD3G

Across TCGA pan-cancer cohorts, CD3G RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CD3G data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CD3G RNA is associated with better overall survival. In most high-consensus cancer types, elevated CD3G expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, UCEC, and HNSC are the cancer types where CD3G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.424	0.255	<.001	132	view →
UCEC	OS	Quartile	All	0.789	0.566	.001	116	view →
HNSC	DFS	Median	All	0.754	0.634	<.001	108	view →
BLCA	OS	Quartile	III,IV	0.767	0.565	.001	84	view →
UVM	OS	Quartile	All	0.350	0.813	<.001	82	view →
CESC	DFS	Tertile	All	0.835	0.621	<.001	72	view →
OV	OS	Median	All	0.369	0.276	.004	66	view →
LGG	OS	Median	All	0.726	0.881	<.001	50	view →
BRCA	DFS	Tertile	All	0.569	0.474	.003	47	view →
LIHC	DFS	Median	All	0.510	0.353	<.001	32	view →
LUAD	DFS	Median	All	0.749	0.604	.004	29	view →
THYM	OS	Median	All	1.000	0.735	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CD3G–SKCM (OS)

Open the SKCM breakdown →