CD3G

Across TCGA cell cohorts, CD3G mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD3G-associated genes across cancer lineages are PRSS38, MGAT4D, and MBD3L5. Each is linked with CD3G in more than 1 cancer types. Because this analysis shows association rather than direction, both CD3G-to-partner and partner-to-CD3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS38 grouped by CD3G-low versus CD3G-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD3G→partner) and Y-score (partner→CD3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRSS38 →	+0.205	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MGAT4D →	+0.021	+4.922	.006	.009	3	1
SKIN	MBD3L5 →	+0.032	+5.415	<.001	.004	3	1
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRSS38 by CD3G expression — BLOOD_Leukemia

Explore this box plot interactively →