CD37

Across TCGA cell cohorts, CD37 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD37-associated genes across cancer lineages are OR4F4, TBC1D3, and CLDN17. Each is linked with CD37 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD37-to-partner and partner-to-CD37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by CD37-low versus CD37-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD37→partner) and Y-score (partner→CD37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.020	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
LUNG_NSCLC_LUAD	CLDN17 →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPRR2B →	+0.047	+4.887	<.001	.009	3	1
BLOOD_Leukemia	GPR42 →	+0.033	+4.152	<.001	.009	3	1
BLOOD_Leukemia	MYPN →	+0.024	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR4F4 by CD37 expression — LARGE_INTESTINE

Explore this box plot interactively →