CD28

Across TCGA patient cohorts, CD28 protein abundance is significantly associated with the RNA expression of many other genes, with 6,379 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD28-associated genes across cancer lineages are HSDL1, DBNDD1, and FERMT3. Each is linked with CD28 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD28-to-partner and partner-to-CD28 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD28 versus HSDL1 in HNSC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD28→partner) and Y-score (partner→CD28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HSDL1 →	-0.766	-0.613	.004	.006	3	3
HNSC	DBNDD1 →	-1.182	-0.636	<.001	.005	3	3
CCRCC	FERMT3 →	+0.828	+0.385	.007	.002	3	3
LSCC	NUTF2 →	-0.550	-0.510	<.001	<.001	3	2
HNSC	CTCF →	-0.364	-0.685	.003	.003	3	2
HNSC	SLC16A7 →	+1.097	+0.896	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,379 associations by consensus.

CD28 vs HSDL1 — HNSC

Explore this scatter interactively →