CD274

Across TCGA pan-cancer cohorts, CD274 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CD274 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CD274 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CD274 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, SKCM, and UCEC are the cancer types where CD274 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.001	0.871	<.001	15	view →
SKCM	DFS	Median	All	0.293	0.762	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.623	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CD274–COAD (OS)

Open the COAD breakdown →