CD274

Across TCGA pan-cancer cohorts, CD274 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CD274’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CD274 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD274 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

HNSC, STAD, and KIRP are the cancer types where CD274 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD274 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.803	<.001	9	view →
STAD	All	II,III,IV	+1.137	.001	8	view →
KIRP	All	All	+0.762	.001	7	view →
KIRC	Male	All	+0.487	<.001	7	view →
LUSC	All	All	−1.093	<.001	6	view →
UCEC	All	All	−0.839	<.001	4	view →
LUAD	All	All	−0.787	<.001	4	view →
THCA	Male	IV	+0.680	.037	2	view →
PRAD	All	All	−0.411	<.001	2	view →
BLCA	Male	IV	+1.397	.025	1	view →
CHOL	Female	All	+1.176	.025	1	view →
ESCA	All	All	+1.093	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CD274–HNSC

Open the HNSC breakdown →