CD274

Across TCGA patient cohorts, CD274 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD274-associated genes across cancer lineages are JNK_pT183_Y185, SF2, and ATM. Each is linked with CD274 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD274-to-partner and partner-to-CD274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CD274-low versus CD274-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD274→partner) and Y-score (partner→CD274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.189	-3.169	.032	.019	3	1
UCEC	SF2 →	+0.127	+2.834	.026	.034	3	1
UCEC	ATM →	-0.517	-3.321	.029	.010	3	1
UCEC	4E-BP1_pT37_T46 →	-0.603	-3.321	.002	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.731	+2.827	.018	.035	3	1
UCEC	PCNA →	+0.277	+3.000	.014	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by CD274 expression — UCEC

Explore this box plot interactively →