CD274

Across TCGA cell cohorts, CD274 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,788 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CD274-associated GO terms across cancer lineages are Regulation of plasminogen activation, Regulation of protein maturation, and Cellular response to environmental stimulus. Each is linked with CD274 in more than 14 cancer types. Because this analysis shows association rather than direction, both CD274-to-partner and partner-to-CD274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by CD274-low versus CD274-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD274→partner) and Y-score (partner→CD274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of plasminogen activation →	+0.378	+2.231	<.001	<.001	3	15
BONE	Regulation of protein maturation →	+0.225	+1.525	<.001	<.001	3	15
BONE	Cellular response to environmental stimulus →	+0.049	+1.415	<.001	<.001	3	14
BONE	Regulation of protein processing →	+0.206	+1.524	<.001	<.001	3	14
BONE	Cellular response to abiotic stimulus →	+0.049	+1.415	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of extrinsic apoptotic signaling pathway →	+0.093	+2.016	.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,788 associations by consensus.

Regulation of plasminogen activation by CD274 expression — LIVER

Explore this box plot interactively →