CD274

Across TCGA cell cohorts, CD274 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CD274-associated genes across cancer lineages are CCDC60, C1orf146, and OR2H1. Each is linked with CD274 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD274-to-partner and partner-to-CD274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC60 grouped by CD274-low versus CD274-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD274→partner) and Y-score (partner→CD274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
OVARY	GPX5 →	+0.019	+4.228	.001	.006	3	1
OVARY	NLRP2B →	+0.059	+4.392	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CCDC60 by CD274 expression — OVARY

Explore this box plot interactively →