CD27

Across TCGA pan-cancer cohorts, CD27 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CD27 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CD27 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CD27 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where CD27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.729	0.591	<.001	152	view →
SKCM	OS	Median	All	0.442	0.272	<.001	127	view →
CESC	DFS	Median	All	0.830	0.645	<.001	102	view →
BRCA	DFS	Tertile	All	0.595	0.462	<.001	86	view →
UCEC	OS	Tertile	All	0.794	0.535	.004	68	view →
UVM	DFS	Tertile	All	0.424	0.860	<.001	63	view →
LUAD	DFS	Tertile	All	0.849	0.747	.002	54	view →
OV	OS	Tertile	All	0.408	0.278	.008	38	view →
LGG	DFS	Tertile	All	0.648	0.803	<.001	36	view →
LIHC	DFS	Quartile	All	0.721	0.477	.001	22	view →
ACC	DFS	Tertile	All	0.826	0.381	.003	19	view →
SARC	OS	Median	All	0.892	0.783	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CD27–HNSC (OS)

Open the HNSC breakdown →