CD27

Across TCGA pan-cancer cohorts, CD27 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CD27’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CD27 RNA is repressed in tumor relative to normal tissue. In most cancer types CD27 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where CD27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.246	<.001	12	view →
KIRC	Male	All	+2.578	<.001	11	view →
LUAD	Female	All	+1.173	<.001	8	view →
KIRP	All	III,IV	+0.972	.018	5	view →
BRCA	All	All	+0.400	.013	4	view →
READ	All	All	−1.876	.004	3	view →
LIHC	Female	II,III,IV	+0.810	.030	2	view →
HNSC	All	III,IV	+0.670	.041	2	view →
ESCA	All	All	+1.330	.014	1	view →
CHOL	All	All	+1.302	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CD27–COAD

Open the COAD breakdown →