CD226

Across TCGA patient cohorts, CD226 protein abundance is significantly associated with the RNA expression of many other genes, with 2,693 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD226-associated genes across cancer lineages are ZNF831, GRAP2, and ITK. Each is linked with CD226 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD226-to-partner and partner-to-CD226 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD226 versus ZNF831 in UCEC, with a Pearson correlation of 0.95.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD226→partner) and Y-score (partner→CD226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF831 →	+1.876	+0.703	.004	.001	3	3
UCEC	GRAP2 →	+1.696	+0.703	.008	.001	3	2
LUAD	ITK →	+1.121	+0.437	<.001	.002	3	2
LSCC	SLC4A3 →	-1.365	-0.583	<.001	.001	3	2
LSCC	ZAP70 →	+1.087	+0.474	.001	<.001	3	2
LSCC	SLAMF1 →	+0.937	+0.577	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,693 associations by consensus.

CD226 vs ZNF831 — UCEC

Explore this scatter interactively →