CD226

Across TCGA pan-cancer cohorts, CD226 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CD226’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CD226 RNA is repressed in tumor relative to normal tissue. In most cancer types CD226 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and BLCA are the cancer types where CD226 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD226 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.547	<.001	10	view →
LUSC	Male	II,III,IV	−0.886	<.001	8	view →
BLCA	Female	IV	−0.600	.025	7	view →
THCA	Female	All	−0.409	<.001	7	view →
KIRC	Male	All	+0.383	<.001	7	view →
LIHC	Male	All	−0.338	<.001	6	view →
COAD	All	All	−0.201	<.001	6	view →
LUAD	Female	III,IV	−0.634	.015	4	view →
STAD	All	II,III,IV	+0.362	.007	4	view →
KIRP	Female	II,III,IV	−0.464	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CD226–KICH

Open the KICH breakdown →