CD226

Across TCGA patient cohorts, CD226 mutation is significantly associated with the RNA expression of many other genes, with 890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD226-associated genes across cancer lineages are OR6C65, XIRP1, and ZBTB8OS. Each is linked with CD226 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD226-to-partner and partner-to-CD226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C65 grouped by CD226-low versus CD226-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD226→partner) and Y-score (partner→CD226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR6C65 →	+0.015	+4.144	.001	.009	3	2
UCEC	XIRP1 →	+0.175	+3.150	.002	<.001	3	2
UCEC	ZBTB8OS →	+0.404	+4.119	<.001	<.001	3	2
UCEC	SMIM10L2A →	-0.633	-3.437	.006	.005	3	2
UCEC	CDCA2 →	+0.774	+2.716	.002	.003	3	2
UCEC	CIDECP1 →	+0.583	+3.053	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 890 associations by consensus.

OR6C65 by CD226 expression — CESC

Explore this box plot interactively →