CD226

Across TCGA patient cohorts, CD226 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD226-associated genes across cancer lineages are 4E-BP1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with CD226 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD226-to-partner and partner-to-CD226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CD226-low versus CD226-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD226→partner) and Y-score (partner→CD226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.415	+3.000	.004	.035	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.376	-1.687	.049	.044	3	2
UCEC	PDCD4 →	-0.521	-2.321	.009	.033	3	2
UCEC	Cyclin-B1 →	+0.801	+3.321	<.001	.009	3	2
UCEC	eEF2 →	+0.449	+2.321	.003	.034	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.999	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

4E-BP1 by CD226 expression — SKCM

Explore this box plot interactively →