CD226

Across TCGA cell cohorts, CD226 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,657 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CD226-associated GO terms across cancer lineages are Alpha-amino acid catabolic process, Regulation of microtubule cytoskeleton organization, and Regulation of microtubule-based process. Each is linked with CD226 in more than 8 cancer types. Because this analysis shows association rather than direction, both CD226-to-partner and partner-to-CD226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-amino acid catabolic process grouped by CD226-low versus CD226-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD226→partner) and Y-score (partner→CD226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Alpha-amino acid catabolic process →	-0.079	-0.327	.003	<.001	3	9
OVARY	Regulation of microtubule cytoskeleton organization →	+0.049	+0.118	<.001	<.001	3	9
OVARY	Regulation of microtubule-based process →	+0.036	+0.085	.002	.001	3	8
OVARY	Centriole assembly →	+0.073	+0.104	<.001	.001	3	8
LUNG_NSCLC_LUSC	L-amino acid catabolic process →	-0.065	-0.198	<.001	.006	3	8
LUNG_NSCLC_LUSC	Amino acid catabolic process →	-0.056	-0.192	.003	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,657 associations by consensus.

Alpha-amino acid catabolic process by CD226 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →