CD22

Across TCGA patient cohorts, CD22 mutation is significantly associated with the RNA expression of many other genes, with 3,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD22-associated genes across cancer lineages are RNU6-709P, E2F1, and BNIP3P6. Each is linked with CD22 in more than 3 cancer types. Because this analysis shows association rather than direction, both CD22-to-partner and partner-to-CD22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by CD22-low versus CD22-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD22→partner) and Y-score (partner→CD22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-709P →	+0.428	+4.455	<.001	.005	3	4
UCEC	E2F1 →	+0.597	+2.459	.003	<.001	3	4
READ	BNIP3P6 →	+0.349	+4.925	<.001	.004	3	3
HNSC	MIR6865 →	+0.636	+3.835	.003	.009	3	3
LUSC	CEP76 →	+0.621	+3.459	<.001	.005	3	3
LUSC	NDUFA8 →	+0.465	+3.196	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,189 associations by consensus.

RNU6-709P by CD22 expression — BLCA

Explore this box plot interactively →