CD1A

Across TCGA cell cohorts, CD1A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CD1A-associated genes across cancer lineages are HPGDS, OR6F1, and OR1M1. Each is linked with CD1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CD1A-to-partner and partner-to-CD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPGDS grouped by CD1A-low versus CD1A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1A→partner) and Y-score (partner→CD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HPGDS →	+0.045	+4.145	.003	.001	3	2
LUNG_SCLC	OR6F1 →	+0.085	+4.817	<.001	.001	3	1
LUNG_SCLC	OR1M1 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	OR2AK2 →	+0.098	+4.269	.003	.005	3	1
LUNG_SCLC	OR2L5 →	+0.044	+4.269	<.001	.005	3	1
SKIN	FAM71C →	+0.010	+2.925	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HPGDS by CD1A expression — SKIN

Explore this box plot interactively →