CD109

Across TCGA patient cohorts, CD109 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD109-associated genes across cancer lineages are PKC-b-II_pS660, c-Met_pY1235, and N-Ras. Each is linked with CD109 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD109-to-partner and partner-to-CD109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by CD109-low versus CD109-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD109→partner) and Y-score (partner→CD109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.423	-2.898	.001	.001	3	3
COAD	c-Met_pY1235 →	+0.105	+2.459	.006	.018	3	3
UCEC	N-Ras →	-0.115	-3.143	.006	.018	3	3
UCEC	Caspase-8 →	-0.248	-2.558	.005	<.001	3	3
UCEC	Cyclin-E2 →	+0.147	+1.817	.013	.015	3	3
LUAD	MSH2 →	+0.318	+2.186	.020	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

PKC-b-II_pS660 by CD109 expression — COAD

Explore this box plot interactively →