CCZ1

Across TCGA patient cohorts, CCZ1 mutation is significantly associated with the RNA expression of many other genes, with 2,043 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCZ1-associated genes across cancer lineages are DDX52, IGLV2-8, and MIR6857. Each is linked with CCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCZ1-to-partner and partner-to-CCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX52 grouped by CCZ1-low versus CCZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCZ1→partner) and Y-score (partner→CCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX52 →	+0.506	+2.928	.009	.001	3	1
UCEC	IGLV2-8 →	+1.990	+4.000	<.001	<.001	3	1
UCEC	MIR6857 →	+0.331	+3.095	<.001	<.001	3	1
UCEC	GGNBP2 →	+0.391	+2.939	.009	<.001	3	1
UCEC	SAA4 →	-0.770	-3.584	.006	.002	3	1
UCEC	FADS1 →	+1.002	+4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,043 associations by consensus.

DDX52 by CCZ1 expression — UCEC

Explore this box plot interactively →