CCZ1

Across TCGA pan-cancer cohorts, CCZ1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CCZ1 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CCZ1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCZ1 expression acts as an unfavorable survival marker, although some lineages such as READ and THYM show a favorable association.

CESC, KICH, and READ are the cancer types where CCZ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.357	0.660	<.001	108	view →
KICH	DFS	Quartile	II,III,IV	0.468	0.949	.002	58	view →
READ	OS	Quartile	All	1.000	0.831	.001	55	view →
LIHC	DFS	Tertile	All	0.459	0.625	.001	49	view →
UVM	DFS	Median	II,III,IV	0.347	0.662	.006	47	view →
THYM	DFS	Median	All	0.907	0.556	<.001	44	view →
BLCA	DFS	Tertile	IV	0.229	0.677	<.001	31	view →
LGG	DFS	Tertile	All	0.770	0.896	.002	29	view →
ACC	DFS	Quartile	All	0.249	0.700	.001	26	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	18	view →
BRCA	DFS	Quartile	IV	0.315	0.841	.004	16	view →
MESO	OS	Tertile	IV	0.863	0.307	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CCZ1–CESC (DFS)

Open the CESC breakdown →