CCZ1

Across TCGA patient cohorts, CCZ1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCZ1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and MEK1. Each is linked with CCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCZ1-to-partner and partner-to-CCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCZ1-low versus CCZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCZ1→partner) and Y-score (partner→CCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.459	.042	.020	3	1
UCEC	FoxM1 →	+0.339	+3.584	.006	.002	3	1
UCEC	MEK1 →	+0.477	+3.169	.006	.019	3	1
UCEC	p62 Lck ligand →	+0.378	+3.179	.016	.010	3	1
UCEC	PCNA →	+0.293	+2.459	.004	.020	3	1
UCEC	PKC-a →	+0.432	+3.183	.027	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by CCZ1 expression — UCEC

Explore this box plot interactively →