CCZ1

Across TCGA cell cohorts, CCZ1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCZ1-associated genes across cancer lineages are GAGE12E, OR10T2, and APOC4. Each is linked with CCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCZ1-to-partner and partner-to-CCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by CCZ1-low versus CCZ1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCZ1→partner) and Y-score (partner→CCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GAGE12E →	+0.046	+5.614	<.001	.002	3	1
BLOOD_Lymphoma	OR10T2 →	+0.031	+4.643	<.001	.005	3	1
LUNG_NSCLC_LUAD	APOC4 →	+0.050	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.015	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GAGE12E by CCZ1 expression — PANCREAS

Explore this box plot interactively →