Across TCGA patient cohorts, CCT8L2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT8L2-associated genes across cancer lineages are C-Raf, p70-S6K, and ASNS. Each is linked with CCT8L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCT8L2-to-partner and partner-to-CCT8L2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT8L2→partner) and Y-score (partner→CCT8L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.138	+1.765	.001	.013	3	4
LUAD	p70-S6K →	+0.277	+3.321	<.001	.009	3	3
SKCM	ASNS →	+0.375	+1.765	.003	.012	3	3
UCEC	4E-BP1 →	+0.309	+2.321	<.001	.005	3	3
UCEC	Cyclin-B1 →	+0.437	+1.321	.010	.012	3	3
COAD	eIF4E →	+0.210	+2.182	.006	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration

CCT8L2 survival (RNA) · tumor vs normal (RNA) · all CCT8L2 data types