Across TCGA cell cohorts, CCT8L2 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCT8L2-associated genes across cancer lineages are PFN3, C12orf40, and OR8B4. Each is linked with CCT8L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT8L2-to-partner and partner-to-CCT8L2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT8L2→partner) and Y-score (partner→CCT8L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFN3 →	+0.080	+2.560	<.001	.008	3	2
LUNG_SCLC	C12orf40 →	+0.026	+3.058	<.001	.004	3	2
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	TAS2R9 →	+0.045	+2.662	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.008	+3.681	<.001	.009	3	1
LUNG_NSCLC_LUAD	AJAP1 →	+0.551	+3.517	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

CCT8L2 survival (RNA) · tumor vs normal (RNA) · all CCT8L2 data types