CCT7

Across TCGA patient cohorts, CCT7 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT7-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and 14-3-3_beta. Each is linked with CCT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT7-to-partner and partner-to-CCT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCT7-low versus CCT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT7→partner) and Y-score (partner→CCT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.813	+3.189	.002	.010	3	2
UCEC	Cyclin-B1 →	+0.531	+2.700	.036	.006	3	2
UCEC	14-3-3_beta →	-0.114	-3.143	.011	.018	3	1
UCEC	eIF4E →	+0.219	+2.700	.021	.006	2	2
UCEC	Fibronectin →	-0.331	-2.990	.026	.036	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.390	+2.000	.043	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Caspase-7-cleavedD198 by CCT7 expression — UCEC

Explore this box plot interactively →