CCT7

Across TCGA cell cohorts, CCT7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCT7-associated genes across cancer lineages are CD81, SCGB2A1, and AMELX. Each is linked with CCT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT7-to-partner and partner-to-CCT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD81 grouped by CCT7-low versus CCT7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT7→partner) and Y-score (partner→CCT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD81 →	+0.820	+3.131	.001	.008	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.588	+3.392	<.001	.006	3	1
LARGE_INTESTINE	AMELX →	+0.534	+2.745	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
CNS	OOSP2 →	+0.118	+5.321	<.001	.005	3	1
SKIN	OR9I1 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CD81 by CCT7 expression — LARGE_INTESTINE

Explore this box plot interactively →